Computational modeling of pedunculopontine nucleus deep brain stimulation
نویسندگان
چکیده
منابع مشابه
The Pedunculopontine Nucleus as Alternative Target for Deep Brain Stimulation
Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The peduncul...
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Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait freezing and falls. Here, we summarise the clinical application and outcomes reported during the past 10 years. The published dataset is limited, comprising fewer than 100 cases. Furthermore, there is great variability in cl...
متن کاملComputational modeling of deep brain stimulation.
Deep brain stimulation (DBS) is an effective clinical treatment for several medically refractory neurological disorders. However, even after decades of clinical success, explicit understanding of the response of neurons to applied electric fields remains limited, and scientific definition of the therapeutic mechanisms of DBS remains elusive. In addition, it is presently unclear which electrode ...
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Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN...
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The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the supe...
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ژورنال
عنوان ژورنال: Journal of Neural Engineering
سال: 2013
ISSN: 1741-2560,1741-2552
DOI: 10.1088/1741-2560/10/4/045005